Dr. Jasmin Honkamäki

Sleep – The Non-Negotiable Foundation

Sleep is one of the most impactful modifiable health behavior. Short sleep duration and poor sleep quality are independently associated with cardiovascular disease, insulin resistance, weight gain, impaired immune function, cognitive decline, and all-cause mortality. Sleep is the one health parameter which usually has a lot of overlooked areas and room to prioritize rewarding major health benefits.

Foundation

Duration — 7 to 9 hours for most adults. Consistently sleeping under 6 hours is associated with increased cardiovascular risk, impaired glucose metabolism, and reduced cognitive performance. Sleeping consistently over 9 hours is also associated with morbidity. Individual need varies, and the best markers of adequate sleep are waking without an alarm and feeling restored.

Sleep timing and regularity. The circadian system governs nearly every physiological process. Irregular sleep–wake timing disrupts circadian alignment and is independently associated with metabolic dysfunction and cardiovascular risk, even when total sleep duration is adequate. Even social jetlag (SJL = the mismatch between weekday and weekend sleep timing) of more than one hour is common and metabolically relevant.

Sleep architecture. Normal sleep cycles through NREM (non-rapid eye movement) stages 1–3 and REM (rapid eye movement) sleep roughly every 90 minutes. Deep sleep (NREM stage 3, also called SWS = slow-wave sleep) dominates the first half of the night and is critical for tissue repair, growth hormone secretion, and memory consolidation. REM sleep increases toward morning and is important for emotional processing and procedural memory. Alcohol, benzodiazepines, and many sedating medications selectively suppress specific sleep stages, meaning you can sleep a full night and still miss essential restorative phases.

Environment

Temperature. Core body temperature must drop by approximately 1–1.5 °C for sleep onset and maintenance. A cool bedroom, typically 17–19 °C, facilitates this. A warm shower 1–2 hours before bed helps by triggering peripheral vasodilation and subsequent core cooling. Bed materials and clothing that trap heat impair sleep quality measurably.

Light. Light is the dominant guide for the circadian clock. Bright light exposure in the morning advances and stabilizes the circadian phase. In the evening, even moderate light, particularly in the blue spectrum, suppresses melatonin secretion and delays sleep onset. Practical steps: get outdoor light within the first hour after waking, dim indoor lighting in the evening, and use blackout curtains or a sleep mask. Screen use before bed is problematic primarily through its light emission, though cognitive arousal also plays a role.

Noise. Nocturnal noise disrupts sleep architecture even when it does not cause full awakenings. Traffic noise above 40 dB is associated with cardiovascular effects in epidemiological studies. Earplugs or white noise can meaningfully improve sleep quality in noisy environments.

Air quality. Elevated bedroom CO₂ is one of the most common and underrecognized contributors to poor sleep quality. In a closed room where one or two people sleep, the concentration easily rises above 2000 ppm, which can cause awakenings during sleep. This is well above the recommended limit, and studies show that it impairs next-day cognitive performance and perceived sleep quality. Enhanced mechanical ventilation is reasonable. A CO₂ monitor is an inexpensive way to verify whether your bedroom ventilation is actually adequate.

Substances that impair sleep

Caffeine. The half-life of caffeine is approximately 5–6 hours, but varies considerably due to CYP1A2 polymorphisms, and slow metabolizers may still have relevant plasma levels 10–12 hours after intake. Stop caffeine intake by early afternoon at the latest. Many people who report no trouble falling asleep after evening caffeine still show reduced deep sleep on polysomnography (PSG = the gold standard sleep study).

Alcohol. Alcohol is a sedative, not a sleep aid. It shortens sleep onset latency but fragments sleep in the second half of the night, suppresses REM sleep, worsens sleep apnea, and increases nocturnal sympathetic activation. Even moderate intake has measurable effects on HRV (heart rate variability) and sleep architecture. The dose–response is clear: less is better for sleep, and no amount improves it.

Nicotine. A stimulant that increases sleep onset latency and reduces total sleep time. Nocturnal withdrawal in regular users also fragments sleep.

Conditions worth screening and treating for

Obstructive sleep apnea (OSA). Highly prevalent, estimated at 10–30 % in middle-aged adults depending on criteria, and substantially underdiagnosed. Risk factors include male sex, obesity, large neck circumference, and anatomical features, but lean individuals and women are also affected. OSA independently increases cardiovascular and metabolic risk. Snoring, witnessed apneas, excessive daytime sleepiness, and morning headaches are classical indicators, but many patients are asymptomatic. Consider screening particularly in treatment-resistant hypertension, atrial fibrillation, and refractory fatigue. Wearables can be indicative for OSA.

Insomnia. Episodes of insomnia are common and stem from a variety of causes. It is essential to identify the underlying reason with sufficient accuracy to prioritize treatment that targets the root cause. In general, Cognitive Behavioral Therapy (CBT) is an effective approach for treating insomnia and proves more successful than medication over the long term. This is because it addresses the specific factors that keep insomnia active even after the original trigger has disappeared. While therapy is often preferred, certain medications can also be helpful. Based on clinical evidence, some of these options are well suited for long term use to help maintain a consistent sleep cycle.

Restless legs syndrome (RLS). Often underdiagnosed. A clinical diagnosis based on an urge to move the legs, worsening at rest and in the evening. Low ferritin (< 75 µg/L in the RLS context) is a modifiable contributor.

Other. Narcolepsy and parasomnias are among more uncommon sleep disorders. Otherwise, many conditions and diseases interplay with or impair sleep, and managing these conditions is essential to remove their possible negative compound effect. Some to mention, menopause, overtraining syndrome, chronic pain, nocturia, and mental health problems are important to take into account.

What matters most

The hierarchy of impact. First, adequate duration: consistently getting enough hours is the single biggest lever. Second, regularity: stable timing protects circadian alignment. Third, environment: cool, dark, quiet.

Tracking and monitoring

Consumer wearables (e.g., Oura) provide reasonable estimates of total sleep time and can be useful for identifying patterns, particularly sleep timing regularity and the effect of alcohol. However, their accuracy for sleep staging, especially deep sleep and REM, remains limited compared to PSG. They can nevertheless help you to understand your sleep habits better and help in optimization, and offer data implying underlying conditions worth investigating more.